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What Is Daxxify? What to Know About the New Botox Alternative

For the previous 20 years, Botox has been the go-to wrinkle-reducing therapy for hundreds of thousands of individuals trying to reduce high-quality traces round their brow, eyes, cheekbones, you title it. There are three related injectables—Dysport, Xeomin, and Jeuveau—however none of those medicine, often known as neuromodulators, have been capable of compete with the recognition of Botox.

Now, some dermatologists say a brand new injectable drug known as Daxxify, just lately accredited by the US Meals and Drug Administration (FDA), might change that. That’s largely as a result of its wrinkle-reducing results are anticipated to last more than different neuromodulators available on the market (together with Botox, the results of which generally final three to 4 months). The gist: As an alternative of scheduling injections three or 4 occasions a 12 months for upkeep, individuals who go for Daxxify might solely want two therapies a 12 months, relying on their private outcomes.

In section three medical trials, researchers examined Daxxify, made by pharmaceutical firm Revance Therapeutics, on practically 2,700 folks. They discovered that roughly 98% of those members skilled a major discount in wrinkles inside 4 weeks of receiving a Daxxify injection. The results kicked in quick, sometimes inside two days of therapy, and lasted six months on common. For a small share of individuals, the outcomes lasted as much as 9 months.

Right here’s what it’s best to learn about Daxxify, together with the way it works, potential downsides, and the way a lot it’s anticipated to price.

How does Daxxify work, precisely?

Like Botox, when Daxxify is injected into the face, it delivers a botulinum toxin to dam sure nerve alerts from interacting with the focused facial muscle mass. This implies the muscle mass are quickly unable to maneuver or contract, stress-free wrinkles and high-quality traces within the course of. Although the muscle mass gained’t operate as they often do, they aren’t truly paralyzed, George Bitar, MD, FACS, a board-certified plastic surgeon in Washington, DC, tells SELF.

Along with having longer-lasting results in comparison with different neuromodulators, Daxxify’s formulation makes use of peptides, that are brief chains of compounds known as amino acids; this makes it the one neuromodulator that’s freed from human serum albumin (a protein present in human blood) or animal-based elements, a spokesperson for Revance tells SELF.

Out there neuromodulators are additionally generally used to alleviate sure well being points, together with migraine, TMJ-related jaw ache, and hyperhidrosis (extreme sweating). For now, Daxxify has solely acquired FDA approval for beauty therapies, however Dr. Bitar expects it could be used for related off-label functions. “I might use Daxxify for a similar issues I’ve used Botox and Dysport for the final 20 years,” he says. That stated, it’s unclear if Daxxify’s outcomes would additionally last more for non-cosmetic considerations.

What are the potential downsides of Daxxify?

To ensure that a drug to obtain FDA approval, it should be deemed protected and efficient. Nevertheless, much like different neuromodulators, you could expertise potential negative effects—like a headache, injection web site ache and swelling, drooping eyelids, and facial asymmetry—after receiving a Daxxify injection.

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